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During the recruitment period, 1,214 eligible individuals were invited; the response rate was 83%. The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Ethical Review Committee of the University of Colombo.

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The aims of this study were to determine the prevalence of different subtypes of diabetes mellitus based on GADA positivity and insulin dependency among South Asians with young adult-onset (16–40 years) diabetes in Sri Lanka and to compare the phenotypic characteristics among the GADA-negative and positive patients.We also examined the association of GADA and fasting C-peptide with requirement for insulin.Glucose and lipid assays were performed using reagents supplied by Roche Diagnostics (Mannheim, Germany) in a Hitachi 704 chemical autoanalyser (Roche Diagnostics) at the Reproductive and Endocrine Laboratory in the University of Colombo.LDL-cholesterol was estimated using the Friedwald equation [] at the National Diabetes Centre in Colombo.Those who were GADA-positive but insulin independent during the first 6 months from diagnosis were termed latent autoimmune diabetes irrespective of age.

The participants with latent autoimmune diabetes aged ≥30 years at diagnosis were considered to have LADA [].Values are shown as mean ± SD, median ± interquartile range (IQR) or percentage with 95% CIs, according to the distribution of the data.The test, Kruskall–Wallis test and Pearson’s correlation test were applied whenever appropriate.There is paucity of information on autoimmune diabetes among South Asians.The available studies with relatively small sample sizes have produced conflicting data. on 269 young South Indians, the prevalence of GADA positivity was reported as 9.0% [] reported prevalences of 1.6% and 3.0%, respectively.S-labelled full-length GAD65, and results were expressed in WHO units/ml derived from a standard curve calibrated from the international reference material (National Institute for Biological Standards and Control code 97/550).